Brown attended Cooper Union and the Parsons School of Design and received a Bachelor of Arts degree in art history and English from New York University in 1956. Brown learned the technical aspects of book design and offset printing while working for a printer doing paste-ups and book jackets from 1958 to 1960. Since 1959 she has been a free-lance illustrator.
Her first book, Marjorie Paradis' Mr. De Luca's Horse, was published in 1962. Since then Brown has illustrated more than forty books and has written and illustrated four of her own, as well as contributed to anthologies, periodicals, and the New York Times. Among the many famous children's authors whose works she has illustrated are Padraic Colum, Margaret Hodges, Elizabeth Coatsworth, Noel Streatfeild, and Andre Norton.
- Mr. De Luca's Horse by Marjorie Paradis (1962)
- Mandy by Julie Andrews Edwards (1971)
- The Secret of the Seven Crows by Wylly Folk St. John (1973)
- When the Sirens Wailed by by Noel Streatfeild (1974)
- King of the Dollhouse by Patricia Clapp (1974)
- An Orphan for Nebraska by Charlene Joy Talbot (1979)